Raymond J Pickles Selected Research

P-2165

1/2022

Thiol-based chemical probes exhibit antiviral activity against SARS-CoV-2 via allosteric disulfide disruption in the spike glycoprotein.

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Raymond J Pickles Research Topics

Disease

24	Infections 01/2022 - 12/2004
7	Human Influenza (Influenza) 10/2012 - 01/2005
6	Cystic Fibrosis (Mucoviscidosis) 12/2023 - 01/2004
5	Respiratory Syncytial Virus Infections 01/2024 - 01/2004
5	COVID-19 01/2022 - 01/2021
4	Virus Diseases (Viral Diseases) 03/2016 - 12/2005
3	Paramyxoviridae Infections (Parainfluenza) 11/2012 - 01/2009
2	Respiratory Tract Infections (Respiratory Tract Infection) 10/2021 - 09/2007
2	Airway Obstruction (Choking) 05/2014 - 10/2012
2	Metaplasia 01/2014 - 08/2011
2	Inflammation (Inflammations) 10/2012 - 05/2011
2	Bacterial Infections (Bacterial Infection) 09/2011 - 10/2005
2	Influenza in Birds (Avian Flu) 02/2011 - 05/2009
1	Bronchiolitis 01/2024
1	Airway Remodeling 01/2024
1	Cytomegalovirus Infections (Inclusion Disease) 10/2019
1	Wounds and Injuries (Trauma) 01/2014
1	Hyperplasia 10/2012
1	Lung Diseases (Lung Disease) 01/2004

Drug/Important Bio-Agent (IBA)

7	Antiviral Agents (Antivirals)IBA 01/2022 - 09/2007
7	Proteins (Proteins, Gene)FDA Link 05/2014 - 08/2008
5	MucinsIBA 10/2012 - 12/2004
4	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 05/2011 - 12/2009
3	Monoclonal AntibodiesIBA 01/2024 - 03/2016
3	Glycoproteins (Glycoprotein)IBA 01/2022 - 01/2009
3	CytokinesIBA 01/2021 - 05/2005
3	VaccinesIBA 03/2016 - 09/2007
3	Phenobarbital (Luminal)FDA Link 10/2012 - 12/2005
3	N-Acetylneuraminic Acid (Sialic Acid)IBA 12/2011 - 01/2005
3	Neuraminidase (Sialidase)IBA 05/2009 - 01/2005
2	Detergents (Detergent)IBA 01/2022 - 05/2021
2	Interferon Type IIBA 01/2021 - 08/2008
2	ChemokinesIBA 01/2021 - 01/2004
2	Interleukin-6 (Interleukin 6)IBA 06/2011 - 05/2005
2	Hemagglutinins (Hemagglutinin)IBA 02/2011 - 05/2009
2	Chemokine CCL5IBA 05/2005 - 01/2004
2	InterleukinsIBA 05/2005 - 01/2004
1	Palivizumab FDA Link 01/2024
1	P-2165IBA 01/2022
1	Complement System Proteins (Complement)IBA 01/2022
1	(2R,3R,4R,5S)- 6- (((2S,3R,4R,5R)- 2,3,4,5,6- pentahydroxyhexyl)- (2- (4- (sulfanylmethyl)phenoxy)ethyl)amino)hexane- 1,2,3,4,5- pentolIBA 01/2022
1	Angiotensin-Converting Enzyme 2IBA 01/2022
1	Sulfhydryl Compounds (Thiols)IBA 01/2022
1	Reducing AgentsIBA 01/2022
1	molnupiravirIBA 01/2021
1	AntigensIBA 10/2019
1	Vitamin D FDA LinkGeneric 01/2014
1	Proline (L-Proline)FDA Link 01/2014
1	PlasticsIBA 01/2013
1	Messenger RNA (mRNA)IBA 10/2012
1	Sialic AcidsIBA 10/2012
1	NucleotidesIBA 08/2011
1	Interleukin-13IBA 08/2011
1	4- (2- (4- isopropylbenzamido)ethoxy)benzoic acidIBA 06/2011
1	RNA (Ribonucleic Acid)IBA 06/2011
1	CalnexinIBA 05/2011
1	Small Interfering RNA (siRNA)IBA 05/2011
1	Protein Isoforms (Isoforms)IBA 02/2011
1	Fetal Proteins (Fetoprotein)IBA 12/2010
1	Virulence Factors (Pathogenicity Factors)IBA 08/2010
1	Chloride Channels (Chloride Channel)IBA 08/2010
1	avian influenza A virus hemagglutininIBA 11/2009
1	GTP-Binding Proteins (G-Protein)IBA 10/2009
1	GlycosaminoglycansIBA 10/2009
1	Membrane Glycoproteins (Membrane Glycoprotein)IBA 05/2009
1	Viral RNAIBA 04/2009
1	InflammasomesIBA 04/2009
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2009
1	Viral ProteinsIBA 01/2009
1	InterferonsIBA 01/2009
1	Green Fluorescent ProteinsIBA 12/2008
1	Caspase 3 (Caspase-3)IBA 09/2008
1	Immune Sera (Antisera)IBA 12/2005
1	Adenosine Triphosphatases (ATPase)IBA 10/2005
1	Adenosine (Adenocard)FDA LinkGeneric 10/2005
1	Adenosine Triphosphate (ATP)IBA 10/2005
1	ImmunosorbentsIBA 05/2005
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2005
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 05/2005
1	EnzymesIBA 05/2005
1	Interleukin-8 (Interleukin 8)IBA 05/2005
1	enhanced green fluorescent proteinIBA 01/2005

Therapy/Procedure

4	Therapeutics 01/2022 - 01/2004
1	Cell- and Tissue-Based Therapy (Cell Therapy) 12/2023
1	Nebulizers and Vaporizers (Inhaler) 10/2021
1	Immunotherapy 10/2021